Progressive transmission of medical images

A novel adaptive source-channel coding scheme for progressive transmission of medical images with a feedback system is therefore proposed in this dissertation. The overall design includes Discrete Wavelet Transform (DWT), Embedded Zerotree Wavelet (EZW) coding, Joint Source-Channel Coding (JSCC), prioritization of region of interest (RoI), variability of parity length based on feedback, and the corresponding hardware design utilising Simulink. The JSCC can achieve an efficient transmission by incorporating unequal error projection (UEP) and rate allocation. An algorithm is also developed to estimate the number of erroneous data in the receiver. The algorithm detects the address in which the number of symbols for each subblock is indicated, and reassigns an estimated correct data according to a decision making criterion, if error data is detected. The proposed system has been designed based on Simulink which can be used to generate netlist for portable devices. A new compression method called Compressive Sensing (CS) is also revisited in this work. CS exhibits many advantages in comparison with EZW based on our experimental results. DICOM JPEG2000 is an efficient coding standard for lossy or lossless multi-component image coding. However, it does not provide any mechanism for automatic RoI definition, and is more complex compared to our proposed scheme. The proposed system significantly reduces the transmission time, lowers computation cost, and maintains an error-free state in the RoI with regards to the above provided features. A MATLAB-based TCP/IP connection is established to demonstrate the efficacy of the proposed interactive and adaptive progressive transmission system. The proposed system is simulated for both binary and symmetric channel (BSC) and Rayleigh channel. The experimental results confirm the effectiveness of the design.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Progressive transmission of medical images

A novel adaptive source-channel coding scheme for progressive transmission of medical images with a feedback system is therefore proposed in this dissertation. The overall design includes Discrete Wavelet Transform (DWT), Embedded Zerotree Wavelet (EZW) coding, Joint Source-Channel Coding (JSCC), prioritization of region of interest (RoI), variability of parity length based on feedback, and the corresponding hardware design utilising Simulink. The JSCC can achieve an efficient transmission by incorporating unequal error projection (UEP) and rate allocation. An algorithm is also developed to estimate the number of erroneous data in the receiver. The algorithm detects the address in which the number of symbols for each subblock is indicated, and reassigns an estimated correct data according to a decision making criterion, if error data is detected. The proposed system has been designed based on Simulink which can be used to generate netlist for portable devices. A new compression method called Compressive Sensing (CS) is also revisited in this work. CS exhibits many advantages in comparison with EZW based on our experimental results. DICOM JPEG2000 is an efficient coding standard for lossy or lossless multi-component image coding. However, it does not provide any mechanism for automatic RoI definition, and is more complex compared to our proposed scheme. The proposed system significantly reduces the transmission time, lowers computation cost, and maintains an error-free state in the RoI with regards to the above provided features. A MATLAB-based TCP/IP connection is established to demonstrate the efficacy of the proposed interactive and adaptive progressive transmission system. The proposed system is simulated for both binary and symmetric channel (BSC) and Rayleigh channel. The experimental results confirm the effectiveness of the desig

An Adaptive Source-Channel Coding with Feedback for Progressive Transmission of Medical Images

A novel adaptive source-channel coding with feedback for progressive transmission of medical images is proposed here. In the source coding part, the transmission starts from the region of interest (RoI). The parity length in the channel code varies with respect to both the proximity of the image subblock to the RoI and the channel noise, which is iteratively estimated in the receiver. The overall transmitted data can be controlled by the user (clinician). In the case of medical data transmission, it is vital to keep the distortion level under control as in most of the cases certain clinically important regions have to be transmitted without any visible error. The proposed system significantly reduces the transmission time and error. Moreover, the system is very user friendly since the selection of the RoI, its size, overall code rate, and a number of test features such as noise level can be set by the users in both ends. A MATLAB-based TCP/IP connection has been established to demonstrate the proposed interactive and adaptive progressive transmission system. The proposed system is simulated for both binary symmetric channel (BSC) and Rayleigh channel. The experimental results verify the effectiveness of the design

Mechanics of Optimal Structural Design for Extreme Loads to Peak System Responses

[[abstract]]Over the past decades, with the development of modern manufacturing and information technology, demands of smart and economical structural designs have been increasing considerably. Central to this engineering issue is that a good structural design needs to embrace both necessary capabilities to afford critical load distributions and the best arrangement of materials serving the performance criteria using limited resources. Here, a new analysis technique is proposed to achieve optimal structural designs considering peak system responses as design constraints respective to extreme load distributions. We anticipate that the technique will open a door for designing efficient structural systems which satisfy safety requirements under various sophisticated loadings from the environment.[[sponsorship]]Tamkang University[[sponsorship]]Taiwan Association of Wind Engineering[[sponsorship]]Institute of Theoretical and Applied Mechanics, Academy of Sciences of the Czech Republic[[conferencetype]]國際[[conferencetkucampus]]淡水校園[[conferencedate]]20151101~20151102[[booktype]]紙本[[iscallforpapers]]Y[[conferencelocation]]New Taipe

Possible detection of hydrazine on Saturn’s moon Rhea

We present the first analysis of far-ultraviolet reflectance spectra of regions on Rhea’s leading and trailing hemispheres collected by the Cassini Ultraviolet Imaging Spectrograph during targeted flybys. In particular, we aim to explain the unidentified broad absorption feature centred near 184 nm. We have used laboratory measurements of the UV spectroscopy of a set of candidate molecules and found a good fit to Rhea’s spectra with both hydrazine monohydrate and several chlorine-containing molecules. Given the radiation-dominated chemistry on the surface of icy satellites embedded within their planets’ magnetospheres, hydrazine monohydrate is argued to be the most plausible candidate for explaining the absorption feature at 184 nm. Hydrazine was also used as a propellant in Cassini’s thrusters, but the thrusters were not used during icy satellite flybys and thus the signal is believed to not arise from spacecraft fuel. We discuss how hydrazine monohydrate may be chemically produced on icy surfaces

Oncologic impact of delay between diagnosis and radical nephroureterectomy

PurposeThis study aimed to evaluate the oncological outcome of delayed surgical wait time from the diagnosis of upper tract urothelial carcinoma (UTUC) to radical nephroureterectomy (RNU).MethodsIn this multicenter retrospective study, medical records were collected between 1988 and 2021 from 18 participating Taiwanese hospitals under the Taiwan UTUC Collaboration Group. Patients were dichotomized into the early (≤90 days) and late (>90 days) surgical wait-time groups. Overall survival, disease-free survival, and bladder recurrence-free survival were calculated using the Kaplan–Meier method and multivariate Cox regression analysis. Multivariate analysis was performed using stepwise linear regression.ResultsOf the 1251 patients, 1181 (94.4%) were classifed into the early surgical wait-time group and 70 (5.6%) into the late surgical wait-time group. The median surgical wait time was 21 days, and the median follow-up was 59.5 months. Our study showed delay-time more than 90 days appeared to be associated with worse overall survival (hazard ratio [HR] 1.974, 95% confidence interval [CI] 1.166−3.343, p = 0.011), and disease-free survival (HR 1.997, 95% CI 1.137−3.507, p = 0.016). This remained as an independent prognostic factor after other confounding factors were adjusted. Age, ECOG performance status, Charlson Comorbidity Index (CCI), surgical margin, tumor location and adjuvant systemic therapy were independent prognostic factors for overall survival. Tumor location and adjuvant systemic therapy were also independent prognostic factors for disease-free survival.ConclusionsFor patients with UTUC undergoing RNU, the surgical wait time should be minimized to less than 90 days. Prolonged delay times may be associated with poor overall and disease-free survival

Characterization of Epstein-Barr Virus miRNAome in Nasopharyngeal Carcinoma by Deep Sequencing

Virus-encoded microRNAs (miRNAs) have been shown to regulate a variety of biological processes involved in viral infection and viral-associated pathogenesis. Epstein-Barr virus (EBV) is a herpesvirus implicated in nasopharyngeal carcinoma (NPC) and other human malignancies. EBV-encoded miRNAs were among the first group of viral miRNAs identified. To understand the roles of EBV miRNAs in the pathogenesis of NPC, we utilized deep sequencing technology to characterize the EBV miRNA transcriptome in clinical NPC tissues. We obtained more than 110,000 sequence reads in NPC samples and identified 44 EBV BART miRNAs, including four new mature miRNAs derived from previously identified BART miRNA precursor hairpins. Further analysis revealed extensive sequence variations (isomiRs) of EBV miRNAs, including terminal isomiRs at both the 5′ and 3′ ends and nucleotide variants. Analysis of EBV genomic sequences indicated that the majority of EBV miRNA nucleotide variants resulted from post-transcriptional modifications. Read counts of individual EBV miRNA in NPC tissue spanned from a few reads to approximately 18,000 reads, confirming the wide expression range of EBV miRNAs. Several EBV miRNAs were expressed at levels similar to highly abundant human miRNAs. Sequence analysis revealed that most of the highly abundant EBV miRNAs share their seed sequences (nucleotides 2–7) with human miRNAs, suggesting that seed sequence content may be an important factor underlying the differential accumulation of BART miRNAs. Interestingly, many of these human miRNAs have been found to be dysregulated in human malignancies, including NPC. These observations not only provide a potential linkage between EBV miRNAs and human malignancy but also suggest a highly coordinated mechanism through which EBV miRNAs may mimic or compete with human miRNAs to affect cellular functions

Survival and prognostic factors for patients with advanced hepatocellular carcinoma after stereotactic ablative radiotherapy.

OBJECTIVE:To evaluate the survival outcomes and prognostic factors of patients with advanced hepatocellular carcinoma (HCC) who underwent stereotactic ablative radiotherapy (SABR). METHODS:This retrospective study evaluated patients with advanced HCC who underwent SABR between December 2007 and July 2015. All patients had Barcelona Clinic Liver Cancer stage C disease and Child-Turcotte-Pugh (CTP) class A-B function. In-field control (IFC), overall survival (OS), prognostic factors, and toxicity were evaluated. RESULTS:In this study of 89 patients, the 3-year IFC rate was 78.1%, and the 1-year and 3-year OS rates were 45.9% and 24.3%, respectively. The multivariate analysis revealed that CTP class, the presence of main portal vein tumor thrombosis, and the presence of extrahepatic spread were independent predictors of OS. The expected median OS values among patients with ≥2, 1, and 0 predictors were 4.2, 8.6, and 26.4 months, respectively (p <0.001). CONCLUSIONS:SABR may be useful for patients with advanced HCC, and patient selection could be based on the CTP classification, main portal vein tumor thrombosis, and extrahepatic spread